New biomarkers of kidney damage and their use in minimally invasive treatment of urolithiasis.

Introduction. The effect of various minimally invasive treatment for kidney stones on renal function has not been sufficiently studied. To assess the specificity, severity, and prognostic significance injury urolithiasis its treatment, it is necessary to search «biomarkers injury». concentration serum urea creatinine used in routine clinical practice, glomerular filtration rate change later stages disease are functional parameters. Materials methods. data were searched PubMed, Web Science, Google Scholar, еLibrary.ru using following keywords: «acute injury», «KIM-1», «kidney molecule 1», «NGAL», «neutrophil gelatinase- associated lipocalin», «L-FABP», «liver-type fatty acid binding protein», «cystatin C», «retrograde intrarenal surgery», «percutaneous nephrolithotomy», urolithiasis», nephrolithiasis». Results. Today new biomarkers have proposed detect at initial stages. These neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, molecule-1 (KIM-1) liver-type protein (L-FABP). level NGAL KIM-1 increases until corresponding histological changes parenchyma develop. In percutaneous nephrolithotomy, multiple punctures postoperative bleeding independent risk factors deterioration long term, large size high density stones, staghorn duration intervention largely with development acute early period. Obstructive uropathy affects damage elimination obstruction leads a decrease urine already dynamics biomarker levels suggests that nephrolithotomy causes more than retrograde surgery (RIRS). Conclusion. Аny may lead injury, which always accompanied by impaired function. mechanisms variants specific features, short-term long-term consequences currently fully determined. Further research evaluating methods condition tubules modern needed.